Endocrine Abstracts

Primary aldosteronism (PA) is generally caused by an adenoma or adrenal hyperplasia. To discern between these two, selective adrenal vein sampling (AVS) is necessary. Adequate interpretation requires that RAAS-interfering medication be withdrawn. We report a patient with severe PA, where it was not possible to safely withdraw RAAS-interfering medication.Case: A 37-year-old male was referred for AVS. He had documented PA and bilateral adrenal adenomas on ...

Context: Lipodystrophy is characterized by subcutaneous fat loss, fat maldistribution, and metabolic syndrome. We present a novel phenotype of partial acquired lipodystrophy, possibly associated with childhood chemotherapy.Case reports: Two adult female patients that had been exposed to intensive cytostatic treatment in childhood for leukemia and aplastic anemia, respectively, were referred for therapy resistant diabetes. Both patients had distinct parti...

The efficacy of human islet transplantation is reduced by loss of islets directly after transplantation. Ischemia is likely to be an important contributing factor to the observed islet loss. Diazoxide inhibits insulin secretion by beta cells and has been shown to exhibit anti-apoptotic and anti-ischemic effects. We hypothesized that preincubation of human islets with diazoxide leads to improved islet survival and graft function.Methods: Isolated human pa...

BackgroundEndogenous Cushing’s syndrome (CS) is detrimental to bone. The skeletal complications are characterized by decreased bone formation and increased bone resorption, resulting in decreased bone mineral density (BMD) and an increased risk of fractures at time of diagnosis. After remission of the disease, BMD improves towards normal values but fracture rate remains elevated. Therefore, components of bone quality other than BMD, such as bone mat...